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穝Θ陈5F-AB-PINACA5F-AMBAB-FUBINACAAMB-FUBINACA﹚┦浪喷

猭腳ま靡絏

Journal Name : Forensic Science And Technology
Author : 赵璟悠；刘超；赵嘉祥；龚丹；杨娅
Institution : 默カそЫ牡や钉{河い牡叭м砃ヴ戮戈}默厩靡懦﹚いみ默カそЫ牡や钉默カそЫ牡や钉默厩靡懦﹚いみ
Year : 2021
Issue : 4
Page : 360

穝弘┦借NPSぇΘ陈SCs琌穝硉程е摸¨郸购媚〃SCsㄣΤ摸ぱ礛陈挡㎝縀笆陈砰CB1㎝CB2的能力，仿大麻效力大于Δ9-THC戳穦璓㏑{1}眖2004瞷材璮ヒ???摸癬JWH-018JWH-250AM-2201单{2-3}祇甶︓材??/?悬?觟摸AB-PINACA5F-AB-PINACA单{4-5}2014稼瑆Ω瞷??/?悬ヒ喹摸AMB5F-AMB单{6-9}碭и瓣嘲尿瞷盢ㄤ恨ǎ獶媚ノ摸陈綤媚珇㎝弘媚珇恨珇贺糤干ヘ魁

硂摸龟喷瑀珇ノ癌琜挡篶э跑耿﹛刮よΑ発磷恨ㄤ珇贺笷κ贺螟の莉夹珇┪癸酚珇ミЧ俱计沮ゑ癸眯畐ㄏ膀糷そ瑀珇浪喷懦﹚羬螟紇臫ンΤ盎快セ╯沮龟喷瞶龟悔ㄒ匡拒??/?悬?觟摸SCsい5F-AB-PINACA AB-FUBINACAのㄤ癸莱??/?悬ヒ喹摸璴ネ5F-AMBAMB-FUBINACA╯ヘ夹1ㄏノGC-MSLC-MS/MSFTIR㎝RSよ猭浪代だ猂が絋靡摸ン浪喷矗ㄑΤм砃も琿㎝计沮把σ

15F-AB-PINACAAB-FUBINACAのㄤ癸莱璴ネ5F-AMBAMB-FUBINACAて厩挡篶

Table 1 Chemical structures of 5F-AB-PINACA or AB-FUBINACA and each individual analogue, the 5F-AMB and AMB-FUBINACA

癌琜挡篶	膀
癌琜挡篶	X=H R1=N R2=C5H10F	X=H R1=N R2=C7H6F
瓜菠	瓜菠	瓜菠
瓜菠	5F-AB-PINACA	AB-FUBINACA
瓜菠	瓜菠	瓜菠
瓜菠	5F-AMB	AMB-FUBINACA

1龟喷场だ

1.1祸竟籔刚警

5975C-7890A︹眯-借眯祸瓣AglientそA&B Qtrap 4500瞒ɡ睪借羛ノ祸瓣SciexそNicolet IN10撑腑跑传眯祸瓣Thermo FisherそDXRxi籈礘陪稬┰耙眯祸瓣Thermo Fisherそ窾だぇ筿ぱキ瓣Mettler ToledoMili-Q禬祸瓣Milipore

SCs癸酚借珹5F-AB-PINACA5F-AMB AB-FUBINACA AMB-FUBINACA夹мΤそ10 mg, ≈99%礚ヒ綣︹眯TEDIA

1.2妓珇矪瞶

だ弘絋嘿SCs癸酚珇5 mgノ礚ヒ綣﹚甧10 mL甧秖瞺い皌Θ0.5 mg/mL睼癸酚珇坊睪ㄑGC-MS代﹚ノ禬祡睦︓0.5μg/mLㄑLC-MS/MS代﹚だぶ秖SCs癸酚珇竚眯祸ATRンホ浪代怠ㄑFTIRだ猂だぶ秖SCs癸酚珇竚件更ㄑRSだ猂

1.3 GC-MSだ猂兵ン

︹眯琖HP-5 MSを灿恨︹眯琖30 m⊙0.25 mm⊙0.25μm瓣Aglientそ更蔼ぃ99.99%瑈秖1.0 mL/min 秈妓放260秈妓秖1μL だ瑈家Α20?1ど放祘﹍放70玂1 min20/min硉瞯ど放︓18010/min硉瞯ど放︓275玂10 min羆笲︽丁28 min 肚块絬放280瞒方EI 臚阑秖70 eV 栋絛瞅50~500 amu 苯磞よΑscan 坊警┑筐3 min

1.4 LC-MS/MSだ猂兵ン

1.4.1 LC场だ

︹眯琖Phenomenex Kinetex? C18琖100 mm⊙3.0 mm⊙2.6μm琖放40瑈笆0.1%ヒ荒禬A㎝0.1%ヒ荒?B辫瑍叉0~1.5 min2% B1.5~6.5 min2%~90% B6.5~9.4 min90%~2% B9.5~12.0 min2% B瑈硉0.4 mL/min 秈妓秖1μL

1.4.2 MS场だ

瞒方筿糛铭筿瞒方ESI+瞒方放550糛铭筿溃5500 V 铭て竟50 psi 徊荐50 psi 卯30 psi 苯磞家ΑMS2㎝MRM SCs玂痙丁の借眯把计ǎ2

2MRM家ΑSCsて玂痙丁㎝纔て借眯だ猂把计

Table 2 Retention time and optimized mass spectrometric parameters of the tested SCs with MRM analysis

て嘿	玂痙丁/min	ダ瞒/m/z 	瞒/m/z 	罫筿溃/e /V	窱疾/e/V 
5F-AB-PINACA	6.76	348.9	304.2*	82.0	21
5F-AB-PINACA	6.76	348.9	233.0	82.0	32
5F-AMB	8.17	364.1	233.1*	78.0	20
5F-AMB	8.17	364.1	304.3	78.0	21
AB-FUBINACA	7.04	369.2	352.2*	90.0	15
AB-FUBINACA	7.04	369.2	324.2	90.0	20
AMB-FUBINACA	8.38	384.0	324.2*	72.0	20
AMB-FUBINACA	8.38	384.0	253.0	72.0	26

猔*﹚秖瞒

1.5 FTIRだ猂兵ン

苯磞絛瞅500~4 000 cm-1 だ侩瞯4 cm-1苯磞Ω计32 Ω伴100 DTGS 浪代竟

1.6 RSだ猂兵ン

苯磞絛瞅100~1 800 cm-1 縀祇猧532nm陪稬描10 描縀瞯4 mW籈礘ふ畖25 μm slit 胣丁5 s

2 挡狦籔癚阶

2.1 GC-MSだ猂挡狦

盢1.2 い妓珇坊睪酚1.3 ┮瓃祸竟兵ン秈︽GC-MS だ猂祇瞷5F-AB-PINACA ㎝5F-AMB玂痙丁だ21.27 ㎝18.95 minㄢ癸莱借眯窰璶疭┖瞒畃常Τm/z 233304145癸伦AB-FUBINACA㎝AMB-FUBIN-ACA玂痙丁だ24.39㎝20.91 minㄢ癸莱借眯窰璶疭┖瞒畃常Τm/z 109253324癸伦パヒ?膀??/?悬?觟/ヒ喹摸SCs窰吊硚畖癸莱挡篶摸疭┖窰吊瞒碭璓度綼CaymanSpectralLibrary眯畐浪ㄤで皌常95%螟絋

2.2 LC-MS/MSだ猂挡狦

沮1┮ボ4贺SCs┮ㄣΤ觟挡篶ESI+家Α借眯瓜Θ[M+H]+だ瞒畃㎝[M+Na]+畃パ5F-AB-PINACA㎝AB-FUBINACAだ挡篶ソ狠ㄣΤ膀临穦[M+H-NH3]+畃沮窰吊诀借眯瓜い 5F-AB-PINACA[M+H]+畃瓜1aアOCH35F-AMB瓜1b[M+H]+畃アNH3ネΘ窰m/z 332C18H23FN3O2+膥τ耞吊玻ネ窰m/z304C17H23FN3O+m/z 233C13H14FN2O+m/z 213C13H13N2O+AB-FUBINACA瓜2a㎝AMB-FU-BINACA瓜2b瓃瞶ネΘ窰m/z 352C20H19FN3O2+m/z 324C19H19FN3O+m/z 253C15H10FN2O+ヘ夹絋薄猵硄筁癸借眯兵ン纔て2秈︽だ猂絋靡狦琌ㄤ挡篶摸玥斗癸ㄤ窰瞒˙崩耞硄筁TOF秈˙絋靡

瓜菠

瓜15F-AB-PINACAa㎝5F-AMBb借眯瓜

Fig.1 MS2 spectrums of 5F-AB-PINACA a and 5F-AMB b

瓜菠

瓜2AB-FUBINACAa㎝AMB-FUBINACAb借眯瓜

Fig.2 MS2 spectrums of AB-FUBINACA a and AMB-FUBINACA b

2.3 FTIRだ猂挡狦

盢1.2い妓珇酚1.5┮瓃祸竟兵ン秈︽FTIRだ猂祇瞷5F-AB-PINACA㎝5F-AMB眯瓜4000~3000 cm-1跋畉钵陪跋だ1700~500 cm-1跋疭┖Μ畃耕伦碔AB-FUBINACA㎝AMB-FUBINACA眯瓜AMB-FUBINACA1732.47 cm-1矪疭┖Μ畃ㄣΤ疭钵┦1700~500 cm-1跋疭┖Μ畃ゑAB-FUBINACAㄣ匡拒┦ǎ瓜34ㄤ璶疭┖畃猧计︗竚ǎ3

2.4 RSだ猂挡狦

盢1.2い妓珇酚1.6┮瓃祸竟兵ン秈︽RSだ猂祇瞷5F-AB-PINACA㎝5F-AMB┰耙眯︗簿畃璶栋い1700~600 cm-1跋ㄣΤ疭┖畃5F-AB-PINACA1200~1000 cm-1跋︗簿畃伦碔繵跋161.93㎝146.36 cm-1矪蛮畃ㄣΤ疭钵┦τ5F-AMB眏畓畃陪蔼繵跋1732.59㎝1666.05 cm-1ㄢ矪畃ㄣΤ疭钵┦AB-FUBINACA㎝AMB-FUBINACA┰耙眯畉钵┦籔5F-AB-PINACA㎝5F-AMBAB-FUBINACA繵跋159.99 cm-1矪︗簿畃㎝AMB-FUBINACA蔼繵跋1732.08㎝1664.47cm-1ㄢ矪畃跋だㄢㄌ沮ǎ瓜56ㄤ璶︗簿畃繵瞯ǎ4

瓜菠

瓜35F-AB-PINACAa㎝5F-AMBb眯瓜

Fig.3 FTIR spectra of 5F-AB-PINACA a and 5F-AMB b

瓜菠

瓜4AB-FUBINACAa㎝AMB-FUBINACAb眯瓜

Fig.4 FTIR spectra of AB-FUBINACA a and AMB-FUBINACA b

35F-AB-PINACA5F-AMBAB-FUBINACA AMB-FUBINACA疭┖Μ畃猧计

Table 3 Characteristic absorption peaks of 5F-AB-PINACA, 5F-AMB, AB-FUBINACA, AMB-FUBINACA

嘿	疭┖Μ畃猧计/cm-1
5F-AB- PINACA	3374.05,3288.31,2943.15,1674.71,1528.72,1490.99,1371.75,1320.25, 1303.18,1215.13,1168.77,1059.01,1020.74,957.16,750.82,648.65
5F-AMB	3412.58,2965.81,1730.27,1666.56,1524.26,1491.27,1335.40,1308.22, 1205.84,1170.03,1151.63,996.64,919.01,815.83,754.77,670.50
AB-FUB INACA	3366.02,1644.57,1512.74,1488.97,1433.57,1300.40,1226.22,1171.15, 1104.27,1010.57,752.04
AMB-FU BINACA	3403.13,2957.26,1732.47,1662.77,1524.33,1488.76,1317.08,1253.16, 1166.98,1003.11,816.96,781.46,752.76,616.28

瓜菠

瓜55F-AB-PINACAa㎝5F-AMBb┰耙眯瓜

Fig.5 Raman spectra of 5F-AB-PINACA a and 5F-AMB b

瓜菠

瓜6AB-FUBINACAa㎝AMB-FUBINACAb┰耙眯瓜

Fig.6 Raman spectra of AB-FUBINACA a and AMB-FUBINACA b

45F-AB-PINACA5F-AMBAB-FUBINACA AMB-FUBINACA┰耙璶︗簿繵瞯

Table 4 Raman shift frequencies of 5F-AB-PINACA, 5F-AMB, AB-FUBINACA, AMB-FUBINACA

嘿	┰耙璶︗簿繵瞯/cm-1
5F-AB-PINA CA1	644.65,1572.68,1491.68,1476.11,1405.12,1383.12,1356.16,1320. 42,1264.85,1153.64,1134.83,1092.52,1002.73,886.82,787.62,761 .50,621.65, 290.99,161.93,146.36
5F-AMB	1732.59,1668.05,1619.42,1575.22,1528.03,1471.87,1408.66,1361 .61,1239.96,1210.98,1005.69,919.76,778.17,751.54,148.88
AB-FUBINAC A	1647.21,1571.01,1528.03,1474.53,1403.92,1356.86,1267.94,1226 .40,1159.32,1001.58,884.12,852.70,829.93,766.80,337.25,159.9 9
AMB-FUBINA CA	1732.08,1664.47,1616.50,1575.79,1526.39,1469.48,1401.75,1359 .73,1220.87,1002.82,902.16,853.46,763.63,621.56,168.63

3挡阶

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